Synthesis of novel heterocyclic compounds: routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation

Kumar, Ajay and Husain, Mofazzal and Prasad, Ashok K. and Singh, Iswar and Vats, Archana and Sharma, Nawal K. and Sharma, Sunil K. and Gupta, Rajinder K. and Olsen, Carl E. and Bracke, Marc E. and Gross, Richard A. and Parmar, Virinder S. (2003) Synthesis of novel heterocyclic compounds: routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation. Indian Journal of Chemistry : Section B, Oganic Chemistry including Medicinal Chemistry, 42 (8). pp. 1950-1957. ISSN 0376-4699

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Item Type:Article
Item Status:Live Archive

Abstract

A series of 5-aryl-3-cyanomethylpyrazoles have been synthesized by refluxing 6-aryl-3-cyano-4-methylthio-2H-pyran-2-ones with hydrazine. The active methylene moiety of these pyrazoles has further been exploited to build 1,4-disubstituted 5-amino-1,2,3-triazoles via their base-catalyzed condensation with 3/4-nitrophenyl azides. All these compounds have been characterized by detailed spectral analysis and chemical transformations to confirm their structures unambiguously, which were proposed inconclusively five decades ago. Further, these pyrazolyltriazoles have been tested as antiinvasive agents against solid tumors and as antimycobacterial agents.

Keywords:Synthesis, Chemistry
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:11306
Deposited On:25 Jul 2013 15:45

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