Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications, 45 (22). pp. 3276-3278. ISSN 1359-7345

Full content URL: http://dx.doi.org/10.1039/b904185k

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Item Type:Article
Item Status:Live Archive

Abstract

Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

Additional Information:First published online 22 Apr 2009
Keywords:Oligonucleotides
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:11301
Deposited On:24 Jul 2013 13:06

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