A case of small cell carcinoma of the prostate and review of the literature

Addeo, Alfredo and Rinaldi, Ciro and Panades, Miguel (2012) A case of small cell carcinoma of the prostate and review of the literature. Tumori, 98 (3). e76-e78. ISSN 0300-8916

Full content URL: http://dx.doi.org/10.1700/1125.12415

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Item Type:Article
Item Status:Live Archive

Abstract

Aim and background. Small cell carcinoma of the prostate (SCCP) is a relatively rare entity, an aggressive tumor with a tendency to metastasize early. There is no standard chemotherapy regimen for SCCP. We report the case of a 67-year-old man with an initial diagnosis of prostate adenocarcinoma with bone metastases who subsequently developed a small cell carcinoma of the prostate with liver metastases. Methods and study design. A review of this case and of the current literature was done with a view to highlighting the ideal approach to such an unusual tumor. Results and conclusion. The patient was treated with carboplatin and etoposide and after 3 cycles achieved a good response. Unfortunately he developed massive pulmonary embolism which impeded the continuation of treatment and caused his death. By reviewing the literature we found there is no standard of care and new targeted therapies have failed to prove any benefit so far. It is mandatory to persevere in planning trials and exploring new drugs to improve the outcome of patients with SCCP. It might also be worth creating a register for SCCP where data can be collected to coordinate the management of these patients and to establish better connections among cancer centers.

Keywords:alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, carboplatin, CD56 antigen, chromogranin, cytokeratin AE1, cytokeratin AE3, etoposide, Ki 67 antigen, leuprorelin, neuron specific enolase, prostate specific antigen, thyroid transcription factor 1, aged, alanine aminotransferase blood level, alkaline phosphatase blood level, article, aspartate aminotransferase blood level, backache, bilirubin blood level, bone metastasis, bone scintiscanning, cancer palliative therapy, cancer radiotherapy, case report, cause of death, differential diagnosis, digital rectal examination, drug dose reduction, drug response, Gleason score, hip pain, human, human tissue, limb weakness, liver biopsy, liver metastasis, lung embolism, male, multiple cycle treatment, nuclear magnetic resonance imaging, prostate adenocarcinoma, prostate biopsy, prostate hypertrophy, rectum biopsy, small cell carcinoma, small cell carcinoma of the prostate, spinal cord compression, Aged, Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Small Cell, Fatal Outcome, Humans, Leuprolide, Liver Neoplasms, Prostate-Specific Antigen, Prostatic Neoplasms, Pulmonary Embolism, Tumor Markers, Biological
Subjects:B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
B Subjects allied to Medicine > B130 Pathology
Divisions:College of Science > School of Life Sciences
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ID Code:11086
Deposited On:22 Jul 2013 15:51

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