Synaptic deficiency in Alzheimer disease and its implications on thalamic and cortical oscillations: a study using a neural mass model

sen Bhattacharya, Basabdatta and Coyle, Damien and Maguire, Liam (2011) Synaptic deficiency in Alzheimer disease and its implications on thalamic and cortical oscillations: a study using a neural mass model. In: 11th UKCI workshop, 7th-9th September 2011, Manchester.

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive

Abstract

This paper studies the effects of varying the total
number of synapses in a computational model of a thalamocortico-thalamic circuitry. The aim is to study overall EEG
slowing in Alzheimer disease (AD) indicated by an increase in
power within the delta (0.5-3 Hz) and theta (3.5-7 Hz) bands
and a decrease in power within the alpha (7.5-13 Hz) and beta
(13.5-20 Hz) frequency bands. We observe a systematic shift
in peak power of the model output from the highest (beta) to
the lowest (delta) frequency band with intra-thalamic synaptic
depletion. This conforms to an overall EEG slowing observed
in AD. Furthermore, the power in all bands stabilise beyond
a certain threshold and do not change with further increase
in synaptic connectivity. This implies redundancy in synaptic
pathways of the thalamo-cortical circuitry and conforms to the
theory of cognitive reserve in AD.

Keywords:brain oscillations, Alzheimers Disease, neural mass model
Subjects:G Mathematical and Computer Sciences > G730 Neural Computing
Divisions:College of Science > School of Engineering
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ID Code:10599
Deposited On:30 Jun 2013 19:37

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