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Identification of an oculomotor biomarker of preclinical Huntington disease

Golding, C. V. P. and Danchaivijitr, C. and Hodgson, T. L. and Tabrizi, S. J. and Kennard, C. (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology, 67 (3). pp. 485-487. ISSN 0028-3878

Full content URL: http://dx.doi.org/10.1212/01.wnl.0000218215.43328....

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Item Type:Article
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Abstract

The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD. Copyright © 2006 by AAN Enterprises, Inc.

Additional Information:Published online before print April 19, 2006
Keywords:adult, article, clinical article, controlled study, cornea reflex, disease course, eye movement control, female, genetics, human, Huntington chorea, male, priority journal, saccadic eye movement, voluntary movement, Adult, Biological Markers, Disease Progression, Humans, Huntington Disease, Middle Aged, Ocular Motility Disorders, Saccades
Subjects:C Biological Sciences > C800 Psychology
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Social Science > School of Psychology
ID Code:10533
Deposited On:25 Jun 2013 09:34

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